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KMID : 0545120220320070918
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Journal of Microbiology and Biotechnology
2022 Volume.32 No. 7 p.918 ~ p.926
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Induction of Cell Cycle Arrest, Apoptosis, and Reducing the Expression of MCM Proteins in Human Lung Carcinoma A549 Cells by Cedrol, Isolated from Juniperus chinensis
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Yun Hee-Jung
Jeoung Da-Jeoung
Jin Soo-Jung
Park Jung-Ha
Lee Eun-Woo
Lee Hyun-Tai
Choi Yung-Hyun
Kim Byung-Woo
Kwon Hyun-Ju
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Abstract
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Proteins related to DNA replication have been proposed as cancer biomarkers and targets for anticancer agents. Among them, minichromosome maintenance (MCM) proteins, often overexpressed in various cancer cells, are recognized both as notable biomarkers for cancer diagnosis and as targets for cancer treatment. Here, we investigated the activity of cedrol, a single compound isolated from Juniperus chinensis, in reducing the expression of MCM proteins in human lung carcinoma A549 cells. Remarkably, cedrol also strongly inhibited the expression of all other MCM protein family members in A549 cells. Moreover, cedrol treatment reduced cell viability in A549 cells, accompanied by cell cycle arrest at the G1 phase, and enhanced apoptosis. Taken together, this study broadens our understanding of how cedrol executes its anticancer activity while demonstrating that cedrol has potential application in the treatment of human lung cancer as an inhibitor of MCM proteins.
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KEYWORD
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Apoptosis, cedrol, cell cycle arrest, Juniperus chinensis, lung carcinoma A549, minichromosome maintenance proteins
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